DDX5

Across TCGA cell cohorts, DDX5 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDX5-associated genes across cancer lineages are SOX3, SNTG2, and OR2T8. Each is linked with DDX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX5-to-partner and partner-to-DDX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOX3 grouped by DDX5-low versus DDX5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX5→partner) and Y-score (partner→DDX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SOX3 →	+0.016	+3.551	<.001	.009	3	1
LARGE_INTESTINE	SNTG2 →	+0.129	+3.817	.003	.002	3	1
LARGE_INTESTINE	OR2T8 →	+0.165	+3.584	<.001	.004	3	1
LARGE_INTESTINE	SOX1 →	+0.576	+3.252	<.001	.009	3	1
LARGE_INTESTINE	TECRL →	+0.012	+3.562	<.001	.002	3	1
LARGE_INTESTINE	LINGO4 →	+0.166	+3.869	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SOX3 by DDX5 expression — BLOOD_Leukemia

Explore this box plot interactively →