DDX46

Across TCGA patient cohorts, DDX46 protein abundance is significantly associated with the RNA expression of many other genes, with 15,186 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DDX46-associated genes across cancer lineages are SRSF2, SUV39H1, and UMPS. Each is linked with DDX46 in more than 7 cancer types. Because this analysis shows association rather than direction, both DDX46-to-partner and partner-to-DDX46 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DDX46 versus SRSF2 in GBM, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX46→partner) and Y-score (partner→DDX46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SRSF2 →	+0.392	+0.285	<.001	<.001	3	8
BRCA	SUV39H1 →	+0.483	+0.176	<.001	<.001	3	7
LSCC	UMPS →	+0.596	+0.123	<.001	<.001	3	7
OV	LARS1 →	+0.693	+0.259	<.001	<.001	3	7
LSCC	USP21 →	+0.535	+0.155	<.001	<.001	3	7
GBM	CENPH →	+1.180	+0.338	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,186 associations by consensus.

DDX46 vs SRSF2 — GBM

Explore this scatter interactively →