DDX46

Across TCGA patient cohorts, DDX46 mutation is significantly associated with the RNA expression of many other genes, with 4,903 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX46-associated genes across cancer lineages are SLC25A33, PDIK1L, and DCTN4. Each is linked with DDX46 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX46-to-partner and partner-to-DDX46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A33 grouped by DDX46-low versus DDX46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX46→partner) and Y-score (partner→DDX46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC25A33 →	+0.550	+1.955	<.001	<.001	3	3
UCEC	PDIK1L →	+0.349	+1.688	.003	<.001	3	3
UCEC	DCTN4 →	+0.357	+1.809	<.001	.001	3	3
SKCM	LINC01853 →	+0.207	+3.139	<.001	<.001	3	3
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	2
COAD	BPY2DP →	+0.287	+5.824	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,903 associations by consensus.

SLC25A33 by DDX46 expression — UCEC

Explore this box plot interactively →