DDX46

Across TCGA patient cohorts, DDX46 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX46-associated genes across cancer lineages are Caspase-7-cleavedD198, Notch1, and P-Cadherin. Each is linked with DDX46 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX46-to-partner and partner-to-DDX46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DDX46-low versus DDX46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX46→partner) and Y-score (partner→DDX46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.495	+1.945	.005	.002	3	3
UCEC	Notch1 →	+0.136	+1.293	.001	.031	3	2
SKCM	P-Cadherin →	-0.346	-3.000	.016	.036	3	2
UCEC	cIAP →	+0.093	+1.348	.025	.007	3	2
UCEC	4E-BP1 →	+0.254	+3.700	.001	.001	3	2
UCEC	Di-Ras3 →	-0.166	-4.074	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Caspase-7-cleavedD198 by DDX46 expression — UCEC

Explore this box plot interactively →