Across TCGA patient cohorts, DDX42 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX42-associated genes across cancer lineages are FoxM1, ATM, and BRCA2. Each is linked with DDX42 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX42-to-partner and partner-to-DDX42 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX42→partner) and Y-score (partner→DDX42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.237	+2.536	.002	<.001	3	2
UCEC	ATM →	-0.545	-2.222	<.001	<.001	3	2
UCEC	BRCA2 →	-0.129	-2.652	<.001	<.001	3	2
UCEC	4E-BP1_pT37_T46 →	-0.255	-1.401	.026	.040	3	2
UCEC	4E-BP1 →	+0.193	+2.700	.020	.005	3	2
UCEC	EGFR →	-0.175	-2.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

DDX42 survival (RNA) · tumor vs normal (RNA) · all DDX42 data types