DDX4

Across TCGA patient cohorts, DDX4 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX4-associated genes across cancer lineages are PDCD4, eIF4E, and JNK2. Each is linked with DDX4 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX4-to-partner and partner-to-DDX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by DDX4-low versus DDX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX4→partner) and Y-score (partner→DDX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.480	-1.807	.001	.024	3	3
UCEC	eIF4E →	+0.155	+2.321	.025	.005	3	2
UCEC	JNK2 →	+0.153	+1.652	.019	.006	3	2
UCEC	MEK1 →	+0.471	+2.643	<.001	<.001	3	2
UCEC	Notch1 →	+0.171	+2.097	<.001	.003	3	2
UCEC	PCNA →	+0.221	+1.938	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

PDCD4 by DDX4 expression — UCEC

Explore this box plot interactively →