DDX4

Across TCGA cell cohorts, DDX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 731 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DDX4-associated GO terms across cancer lineages are Chiasma assembly, Regulation of TORC1 signaling, and Negative regulation of telomere maintenance. Each is linked with DDX4 in more than 4 cancer types. Because this analysis shows association rather than direction, both DDX4-to-partner and partner-to-DDX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chiasma assembly grouped by DDX4-low versus DDX4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX4→partner) and Y-score (partner→DDX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Chiasma assembly →	+0.202	+0.030	<.001	.007	3	5
KIDNEY	Regulation of TORC1 signaling →	+0.034	+0.038	.001	.002	3	5
LUNG_NSCLC_LUSC	Negative regulation of telomere maintenance →	+0.069	+0.044	.001	.009	2	5
OVARY	Cardiolipin metabolic process →	+0.068	+0.090	.001	.001	3	4
OVARY	Positive regulation of TORC1 signaling →	+0.041	+0.060	.007	.002	2	5
LUNG_SCLC	Regulation of TOR signaling →	+0.050	+0.093	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 731 associations by consensus.

Chiasma assembly by DDX4 expression — LARGE_INTESTINE

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