DDX4

Across TCGA cell cohorts, DDX4 mutation is significantly associated with the mutation status of many other genes, with 5,403 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDX4-associated genes across cancer lineages are ACLY, CLCN2, and PTPRA. Each is linked with DDX4 in more than 4 cancer types. Because this analysis shows association rather than direction, both DDX4-to-partner and partner-to-DDX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACLY grouped by DDX4-low versus DDX4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX4→partner) and Y-score (partner→DDX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ACLY →	+4.772	+5.339	.004	.004	1	5
CNS	CLCN2 →	+4.044	+5.000	.008	.008	1	4
CNS	PTPRA →	+4.459	+5.277	.005	.005	1	4
BLOOD_Lymphoma	ZNF365 →	+3.969	+3.969	.002	.002	1	4
BLOOD_Leukemia	PCDH9 →	+3.145	+3.932	.004	.004	1	4
SKIN	KIF13A →	+3.772	+3.772	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,403 associations by consensus.

ACLY by DDX4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →