DDX3Y

Across TCGA pan-cancer cohorts, DDX3Y mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DDX3Y data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DDX3Y mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DDX3Y expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, LSCC, and GBM are the cancer types where DDX3Y mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	1.000	0.449	.032	3	view →
LSCC	DFS	Median	II,III,IV	0.451	0.877	.044	3	view →
GBM	DFS	Median	All	0.298	0.443	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DDX3Y–CCRCC (OS)

Open the CCRCC breakdown →