DDX3Y

Across TCGA pan-cancer cohorts, DDX3Y RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DDX3Y’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where DDX3Y RNA is repressed in tumor relative to normal tissue. In most cancer types DDX3Y is over-expressed in tumor, although a few such as KIRP and UCEC show the opposite, repressed pattern.

KIRP, UCEC, and BLCA are the cancer types where DDX3Y tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDX3Y RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	II,III,IV	−2.557	<.001	6	view →
UCEC	All	All	−0.016	.011	6	view →
BLCA	Male	All	−1.472	.009	5	view →
KICH	Male	II,III,IV	−2.184	.001	4	view →
LUSC	Male	All	−1.076	<.001	2	view →
STAD	Male	All	−0.849	.007	2	view →
LUAD	Male	All	−0.803	<.001	2	view →
PRAD	All	All	−0.318	.024	2	view →
THCA	Male	III,IV	−0.982	.002	1	view →
KIRC	Male	All	−0.401	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DDX3Y–KIRP

Open the KIRP breakdown →