DDX3Y

Across TCGA patient cohorts, DDX3Y mutation is significantly associated with the RNA expression of many other genes, with 82 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DDX3Y-associated genes across cancer lineages are OR4A49P, FAM47DP, and RN7SL242P. Each is linked with DDX3Y in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX3Y-to-partner and partner-to-DDX3Y results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4A49P grouped by DDX3Y-low versus DDX3Y-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX3Y→partner) and Y-score (partner→DDX3Y) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	OR4A49P →	+0.082	+6.008	<.001	.002	3	2
LIHC	FAM47DP →	+0.025	+5.544	<.001	.004	3	2
LIHC	RN7SL242P →	+0.146	+5.647	<.001	.004	3	2
LUSC	GCSHP2 →	+0.166	+5.093	<.001	.008	3	2
SKCM	OR4C15 →	+0.040	+5.328	<.001	.003	3	2
SKCM	RNA5SP68 →	+0.447	+4.867	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

OR4A49P by DDX3Y expression — LIHC

Explore this box plot interactively →