DDX39A

Across TCGA patient cohorts, DDX39A mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX39A-associated genes across cancer lineages are ERK2, Rab25, and Annexin-1. Each is linked with DDX39A in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX39A-to-partner and partner-to-DDX39A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by DDX39A-low versus DDX39A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX39A→partner) and Y-score (partner→DDX39A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.237	+2.222	.003	.011	3	1
UCEC	Rab25 →	-0.382	-1.700	.006	.044	3	1
UCEC	Annexin-1 →	+0.589	+3.341	.008	.005	3	1
UCEC	ATM →	-0.652	-3.308	<.001	.009	3	1
UCEC	BRCA2 →	-0.125	-2.108	.024	.018	3	1
SKCM	Bak →	-0.269	-3.000	.033	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ERK2 by DDX39A expression — UCEC

Explore this box plot interactively →