DDX31

Across TCGA pan-cancer cohorts, DDX31 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DDX31 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DDX31 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DDX31 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where DDX31 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	III,IV	0.875	0.340	.020	17	view →
PDAC	OS	Quartile	II,III,IV	0.362	0.608	.008	16	view →
CCRCC	DFS	Quartile	All	0.971	0.426	.003	10	view →
LSCC	DFS	Median	II,III,IV	0.851	0.530	.005	8	view →
UCEC	DFS	Quartile	III,IV	1.000	0.379	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DDX31–LUAD (DFS)

Open the LUAD breakdown →