DDX31

Across TCGA pan-cancer cohorts, DDX31 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DDX31’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DDX31 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDX31 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, THCA, and HNSC are the cancer types where DDX31 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDX31 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.348	<.001	11	view →
THCA	Male	III,IV	−1.091	<.001	11	view →
HNSC	Male	IV	+1.017	<.001	11	view →
STAD	Male	II,III,IV	+1.380	<.001	9	view →
LIHC	Male	II,III,IV	+0.827	<.001	9	view →
BLCA	All	III,IV	+0.755	<.001	9	view →
READ	All	All	+1.146	<.001	7	view →
LUSC	Male	II,III,IV	+0.516	<.001	7	view →
KIRP	Male	II,III,IV	+0.540	.006	6	view →
BRCA	All	II,III,IV	+0.350	<.001	6	view →
CHOL	Male	All	+2.054	<.001	5	view →
KICH	Female	All	−0.986	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DDX31–COAD

Open the COAD breakdown →