DDX31

Across TCGA patient cohorts, DDX31 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX31-associated genes across cancer lineages are Ku80, 4E-BP1_pT37_T46, and Caspase-7-cleavedD198. Each is linked with DDX31 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX31-to-partner and partner-to-DDX31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by DDX31-low versus DDX31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX31→partner) and Y-score (partner→DDX31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.208	+1.594	.021	.042	3	2
UCEC	4E-BP1_pT37_T46 →	-0.411	-2.687	.004	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.565	+2.135	.013	.010	3	2
UCEC	EGFR_pY1068 →	-0.271	-2.087	.004	.005	3	1
UCEC	eIF4E →	+0.185	+2.183	.022	.033	3	1
UCEC	FOXO3a_pS318_S321 →	-0.096	-1.690	.046	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Ku80 by DDX31 expression — UCEC

Explore this box plot interactively →