DDX31

Across TCGA cell cohorts, DDX31 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,084 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DDX31-associated GO terms across cancer lineages are Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Maturation of 5.8S rRNA. Each is linked with DDX31 in more than 18 cancer types. Because this analysis shows association rather than direction, both DDX31-to-partner and partner-to-DDX31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by DDX31-low versus DDX31-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX31→partner) and Y-score (partner→DDX31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.095	+0.943	<.001	<.001	3	19
BONE	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.162	+0.977	<.001	<.001	3	19
BONE	Maturation of 5.8S rRNA →	+0.205	+1.159	<.001	<.001	3	18
BONE	Transcription by RNA polymerase III →	+0.106	+1.049	<.001	<.001	3	18
BONE	Transcription by RNA polymerase I →	+0.137	+1.040	<.001	<.001	3	18
BONE	DNA-templated transcription termination →	+0.129	+1.014	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,084 associations by consensus.

Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by DDX31 expression — PANCREAS

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