DDX31

Across TCGA cell cohorts, DDX31 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DDX31-associated genes across cancer lineages are RS1, KLRD1, and ZIC3. Each is linked with DDX31 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX31-to-partner and partner-to-DDX31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RS1 grouped by DDX31-low versus DDX31-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX31→partner) and Y-score (partner→DDX31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RS1 →	+0.103	+4.564	.002	.001	3	1
BLOOD_Leukemia	KLRD1 →	+0.283	+3.769	<.001	.008	3	1
BLOOD_Leukemia	ZIC3 →	+0.015	+4.060	<.001	.003	3	1
BLOOD_Leukemia	DCLK3 →	+0.195	+3.769	<.001	.008	3	1
BLOOD_Leukemia	CYP4A11 →	+0.025	+3.705	<.001	.007	3	1
BLOOD_Leukemia	IL1RAPL2 →	+0.259	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

RS1 by DDX31 expression — BLOOD_Leukemia

Explore this box plot interactively →