DDX27

Across TCGA patient cohorts, DDX27 mutation is significantly associated with the RNA expression of many other genes, with 1,623 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX27-associated genes across cancer lineages are RPL23AP82, CHKB-DT, and MTFP1. Each is linked with DDX27 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX27-to-partner and partner-to-DDX27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP82 grouped by DDX27-low versus DDX27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX27→partner) and Y-score (partner→DDX27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL23AP82 →	+0.522	+2.470	<.001	<.001	3	3
UCEC	CHKB-DT →	+0.431	+2.595	.006	.005	3	3
UCEC	MTFP1 →	+0.603	+3.010	<.001	<.001	3	3
UCEC	PHF5A →	+0.479	+2.513	<.001	<.001	3	3
BLCA	RNA5SP176 →	+0.308	+7.640	<.001	.009	3	3
UCEC	CCDC51 →	+0.408	+2.753	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,623 associations by consensus.

RPL23AP82 by DDX27 expression — UCEC

Explore this box plot interactively →