DDX27

Across TCGA pan-cancer cohorts, DDX27 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated DDX27 data layer compared with 9 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher DDX27 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DDX27 expression acts as an unfavorable survival marker, although some lineages such as SCLC and THYM show a favorable association.

LIHC, MESO, and ACC are the cancer types where DDX27 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Tertile	All	0.435	0.626	<.001	101	view →
MESO	OS	Tertile	All	0.266	0.580	<.001	93	view →
ACC	DFS	Median	All	0.228	0.679	<.001	80	view →
UVM	OS	Median	II,III,IV	0.747	0.964	.001	74	view →
KIRP	DFS	Tertile	All	0.749	0.924	<.001	62	view →
KICH	DFS	Median	III,IV	0.240	1.000	.001	57	view →
LGG	DFS	Median	All	0.662	0.809	<.001	50	view →
SCLC	OS	Tertile	All	0.620	0.293	.002	43	view →
UCEC	DFS	Median	All	0.790	0.882	<.001	36	view →
PAAD	DFS	Median	All	0.230	0.502	<.001	34	view →
COAD	DFS	Quartile	All	0.597	0.830	.002	33	view →
HNSC	DFS	Median	All	0.672	0.743	.017	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

DDX27–LIHC (DFS)

Open the LIHC breakdown →