DDX27

Across TCGA patient cohorts, DDX27 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX27-associated genes across cancer lineages are GAPDH, JNK_pT183_Y185, and Notch1. Each is linked with DDX27 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX27-to-partner and partner-to-DDX27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by DDX27-low versus DDX27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX27→partner) and Y-score (partner→DDX27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.410	+2.000	.034	.030	3	2
UCEC	JNK_pT183_Y185 →	-0.194	-3.906	.001	<.001	3	2
UCEC	Notch1 →	+0.127	+1.750	.012	.049	3	2
UCEC	STAT3_pY705 →	-0.356	-2.492	<.001	.001	3	2
UCEC	TFRC →	+0.511	+1.700	.007	.042	3	2
UCEC	Caspase-8 →	-0.243	-1.880	.007	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

GAPDH by DDX27 expression — UCEC

Explore this box plot interactively →