DDX25

Across TCGA patient cohorts, DDX25 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX25-associated genes across cancer lineages are ACC1, PREX1, and TFRC. Each is linked with DDX25 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX25-to-partner and partner-to-DDX25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by DDX25-low versus DDX25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX25→partner) and Y-score (partner→DDX25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.278	+1.222	.018	.035	3	2
UCEC	PREX1 →	-0.238	-2.222	.007	.009	3	2
UCEC	TFRC →	+0.531	+1.925	.002	.004	3	2
UCEC	ASNS →	+0.456	+1.716	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.084	-1.880	.010	.014	3	1
UCEC	EGFR_pY1068 →	-0.193	-1.716	.017	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ACC1 by DDX25 expression — UCEC

Explore this box plot interactively →