DDX25

Across TCGA pan-cancer cohorts, DDX25 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated DDX25 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher DDX25 RNA is associated with better overall survival. In most high-consensus cancer types, elevated DDX25 expression acts as an unfavorable survival marker, although some lineages such as LGG and UCS show a favorable association.

LGG, UCS, and LUAD are the cancer types where DDX25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.514	0.365	<.001	51	view →
UCS	DFS	Quartile	II,III,IV	0.615	0.130	.005	36	view →
LUAD	DFS	Median	IV	0.240	0.843	.001	36	view →
PAAD	DFS	Quartile	All	0.486	0.165	<.001	33	view →
LUSC	DFS	Median	All	0.917	0.680	<.001	26	view →
MESO	OS	Median	IV	0.823	0.325	.004	22	view →
KIRP	DFS	Median	All	0.951	0.865	.004	21	view →
KIRC	OS	Quartile	All	0.755	0.565	<.001	20	view →
SCLC	DFS	Median	All	0.377	0.609	.006	20	view →
UCEC	DFS	Quartile	All	0.501	0.809	.003	20	view →
ACC	DFS	Quartile	All	0.148	0.558	.002	17	view →
BRCA	OS	Quartile	III,IV	0.911	0.776	.025	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

DDX25–LGG (OS)

Open the LGG breakdown →