DDX25

Across TCGA cell cohorts, DDX25 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDX25-associated genes across cancer lineages are IL17F, MYH2, and MYH8. Each is linked with DDX25 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX25-to-partner and partner-to-DDX25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL17F grouped by DDX25-low versus DDX25-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX25→partner) and Y-score (partner→DDX25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IL17F →	+0.056	+3.766	<.001	.004	3	1
LARGE_INTESTINE	MYH2 →	+0.056	+3.994	.004	.002	3	1
LARGE_INTESTINE	MYH8 →	+0.086	+4.242	<.001	.001	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

IL17F by DDX25 expression — LARGE_INTESTINE

Explore this box plot interactively →