DDX25

Across TCGA cell cohorts, DDX25 mutation is significantly associated with the mutation status of many other genes, with 672 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDX25-associated genes across cancer lineages are MANSC1, SHQ1, and CCAR1. Each is linked with DDX25 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX25-to-partner and partner-to-DDX25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MANSC1 grouped by DDX25-low versus DDX25-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX25→partner) and Y-score (partner→DDX25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MANSC1 →	+5.297	+5.297	.004	.004	1	3
BREAST	SHQ1 →	+5.297	+5.297	.004	.004	1	3
BREAST	CCAR1 →	+4.297	+4.857	.009	.009	1	2
BREAST	NCKAP1 →	+4.297	+4.857	.009	.009	1	2
BREAST	CDK13 →	+4.297	+4.857	.009	.009	1	2
LARGE_INTESTINE	KIAA1107 →	+2.196	+4.015	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 672 associations by consensus.

MANSC1 by DDX25 expression — BREAST

Explore this box plot interactively →