DDX24

Across TCGA patient cohorts, DDX24 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX24-associated genes across cancer lineages are GAPDH, 4E-BP1, and FOXO3a_pS318_S321. Each is linked with DDX24 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX24-to-partner and partner-to-DDX24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by DDX24-low versus DDX24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX24→partner) and Y-score (partner→DDX24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.411	+3.459	.020	.005	3	3
SKCM	4E-BP1 →	+0.400	+3.000	.021	.035	3	3
BLCA	FOXO3a_pS318_S321 →	-0.209	-3.169	.001	.017	3	2
BLCA	YAP_pS127 →	-0.514	-3.459	.004	.005	3	2
COAD	RAD51 →	+0.170	+2.815	.049	.036	3	2
COAD	Caspase-7-cleavedD198 →	+1.597	+2.815	<.001	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

GAPDH by DDX24 expression — UCEC

Explore this box plot interactively →