DDX24

Across TCGA pan-cancer cohorts, DDX24 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated DDX24 data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DDX24 RNA is associated with better overall survival. In most high-consensus cancer types, elevated DDX24 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

KIRC, HNSC, and SCLC are the cancer types where DDX24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.707	0.560	<.001	88	view →
HNSC	OS	Median	All	0.704	0.798	<.001	66	view →
SCLC	OS	Tertile	All	0.770	0.432	.001	38	view →
UCEC	DFS	Median	IV	0.720	0.252	.001	36	view →
BLCA	OS	Quartile	II,III,IV	0.633	0.788	.006	33	view →
ACC	OS	Quartile	III,IV	1.000	0.151	.002	31	view →
MESO	OS	Tertile	III,IV	0.738	0.180	.006	24	view →
BRCA	OS	Quartile	III,IV	0.903	0.732	.010	23	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →
SKCM	OS	Quartile	II,III,IV	0.348	0.177	.014	15	view →
LUSC	DFS	Median	III,IV	0.526	0.914	.011	14	view →
UVM	DFS	Tertile	All	0.336	0.586	.016	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

DDX24–KIRC (OS)

Open the KIRC breakdown →