DDX23

Across TCGA patient cohorts, DDX23 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX23-associated genes across cancer lineages are eIF4E, MEK1, and Cyclin-B1. Each is linked with DDX23 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX23-to-partner and partner-to-DDX23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DDX23-low versus DDX23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX23→partner) and Y-score (partner→DDX23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.161	+3.169	.046	.019	3	2
UCEC	MEK1 →	+0.326	+2.000	.020	.030	3	2
UCEC	Cyclin-B1 →	+0.579	+2.584	.007	.001	3	2
COAD	ASNS →	+0.425	+3.008	.038	.019	3	2
BLCA	Tuberin_pT1462 →	+0.295	+2.824	<.001	.036	3	1
UCEC	14-3-3_beta →	-0.092	-3.295	.017	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4E by DDX23 expression — UCEC

Explore this box plot interactively →