DDX23

Across TCGA pan-cancer cohorts, DDX23 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DDX23 data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher DDX23 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DDX23 expression acts as an unfavorable survival marker, although some lineages such as UCEC and KIRC show a favorable association.

MESO, LUAD, and ACC are the cancer types where DDX23 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.415	0.699	.006	66	view →
LUAD	OS	Tertile	All	0.241	0.423	<.001	63	view →
ACC	DFS	Tertile	All	0.196	0.674	<.001	60	view →
LIHC	OS	Median	All	0.708	0.841	<.001	50	view →
UVM	DFS	Quartile	II,III,IV	0.280	0.751	.003	50	view →
UCEC	DFS	Median	III,IV	0.675	0.452	.007	38	view →
HNSC	DFS	Median	All	0.203	0.464	.002	32	view →
KIRC	DFS	Quartile	IV	0.727	0.206	.002	29	view →
THYM	OS	Median	All	1.000	0.712	<.001	20	view →
KICH	OS	Median	All	0.760	0.971	.010	18	view →
LAML	DFS	Tertile	All	0.383	0.606	.005	18	view →
LGG	OS	Quartile	All	0.834	0.942	.003	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DDX23–MESO (OS)

Open the MESO breakdown →