DDX23

Across TCGA cell cohorts, DDX23 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDX23-associated genes across cancer lineages are R3HDML, BANF2, and LRRC74A. Each is linked with DDX23 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX23-to-partner and partner-to-DDX23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HDML grouped by DDX23-low versus DDX23-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX23→partner) and Y-score (partner→DDX23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	BANF2 →	+0.047	+5.643	<.001	.002	3	1
LUNG_NSCLC_LUAD	LRRC74A →	+0.007	+3.944	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR7G1 →	+0.010	+3.944	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR4F4 →	+0.006	+3.472	<.001	.004	3	1
LUNG_NSCLC_LUAD	LCE2A →	+0.031	+3.189	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

R3HDML by DDX23 expression — BLOOD_Lymphoma

Explore this box plot interactively →