DDX21

Across TCGA patient cohorts, DDX21 mutation is significantly associated with the RNA expression of many other genes, with 2,224 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX21-associated genes across cancer lineages are SCAND3P1, RNY4P14, and MIR4727. Each is linked with DDX21 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX21-to-partner and partner-to-DDX21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCAND3P1 grouped by DDX21-low versus DDX21-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX21→partner) and Y-score (partner→DDX21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SCAND3P1 →	+0.154	+4.131	<.001	.002	3	3
CESC	RNY4P14 →	+0.172	+4.144	<.001	.009	3	2
UCEC	MIR4727 →	+0.237	+2.414	.001	.003	3	2
UCEC	IGHD3-3 →	+1.263	+1.905	<.001	<.001	3	2
UCEC	RNU6-380P →	+0.141	+3.470	<.001	.002	3	2
UCEC	RNU7-90P →	+0.227	+2.634	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,224 associations by consensus.

SCAND3P1 by DDX21 expression — BLCA

Explore this box plot interactively →