DDX20

Across TCGA patient cohorts, DDX20 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX20-associated genes across cancer lineages are mTOR_pS2448, eIF4E, and 4E-BP1_pT37_T46. Each is linked with DDX20 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX20-to-partner and partner-to-DDX20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by DDX20-low versus DDX20-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX20→partner) and Y-score (partner→DDX20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	mTOR_pS2448 →	-0.239	-3.321	.011	.010	3	3
UCEC	eIF4E →	+0.252	+2.432	<.001	<.001	3	2
SKCM	4E-BP1_pT37_T46 →	-0.812	-3.169	<.001	.018	3	2
SKCM	Caspase-7-cleavedD198 →	+0.874	+3.025	.003	.018	3	2
SKCM	53BP1 →	+0.533	+3.017	.006	.017	3	2
UCEC	GAPDH →	+0.515	+2.502	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

mTOR_pS2448 by DDX20 expression — SKCM

Explore this box plot interactively →