DDX20

Across TCGA pan-cancer cohorts, DDX20 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DDX20’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DDX20 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDX20 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where DDX20 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDX20 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.664	<.001	12	view →
THCA	All	II,III,IV	−0.496	<.001	10	view →
LIHC	Female	II,III,IV	+0.937	<.001	9	view →
COAD	Male	All	+0.524	<.001	8	view →
BLCA	All	All	+0.446	.003	8	view →
KICH	Female	All	−1.154	<.001	7	view →
STAD	All	II,III,IV	+0.682	<.001	6	view →
CHOL	All	All	+1.942	<.001	5	view →
READ	All	All	+0.467	.005	4	view →
KIRC	All	All	+0.225	.002	4	view →
BRCA	All	II,III,IV	+0.143	.033	3	view →
UCEC	All	IV	−1.120	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

DDX20–HNSC

Open the HNSC breakdown →