DDX20

Across TCGA cell cohorts, DDX20 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDX20-associated genes across cancer lineages are AKAIN1, CST5, and MROH2B. Each is linked with DDX20 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX20-to-partner and partner-to-DDX20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKAIN1 grouped by DDX20-low versus DDX20-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX20→partner) and Y-score (partner→DDX20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	AKAIN1 →	+0.061	+4.017	<.001	.007	3	1
BLOOD_Lymphoma	CST5 →	+0.532	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	MROH2B →	+0.116	+5.643	<.001	.002	3	1
SKIN	IL31 →	+0.032	+4.977	<.001	.007	3	1
LARGE_INTESTINE	GPR171 →	+0.017	+3.688	<.001	.002	3	1
LARGE_INTESTINE	FAM205A →	+0.019	+3.766	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

AKAIN1 by DDX20 expression — OESOPHAGUS

Explore this box plot interactively →