DDX11L2

Across TCGA patient cohorts, DDX11L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,383 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible DDX11L2-associated GO terms across cancer lineages are Positive regulation of DNA repair, Base-excision repair, AP site formation, and Positive regulation of DNA recombination. Each is linked with DDX11L2 in more than 16 cancer types. Because this analysis shows association rather than direction, both DDX11L2-to-partner and partner-to-DDX11L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by DDX11L2-low versus DDX11L2-high in KIRC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX11L2→partner) and Y-score (partner→DDX11L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	Positive regulation of DNA repair →	+0.030	+0.599	<.001	<.001	3	17
KIRC	Base-excision repair, AP site formation →	+0.051	+0.541	<.001	<.001	3	16
KIRC	Positive regulation of DNA recombination →	+0.027	+0.549	<.001	<.001	3	15
KIRC	Mitochondrial gene expression →	+0.028	+0.575	<.001	<.001	3	15
KIRC	Positive regulation of double-strand break repair →	+0.030	+0.551	<.001	<.001	3	14
KIRC	Positive regulation of telomere maintenance →	+0.029	+0.463	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,383 associations by consensus.

Positive regulation of DNA repair by DDX11L2 expression — KIRC

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