DDX11L2

Across TCGA pan-cancer cohorts, DDX11L2 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated DDX11L2 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DDX11L2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DDX11L2 expression acts as an unfavorable survival marker, although some lineages such as DLBC and MESO show a favorable association.

KIRC, ACC, and DLBC are the cancer types where DDX11L2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.738	0.879	<.001	108	view →
ACC	OS	Quartile	III,IV	0.172	0.761	.004	64	view →
DLBC	DFS	Tertile	II,III,IV	0.971	0.518	.004	41	view →
MESO	OS	Median	All	0.725	0.297	.002	30	view →
UCEC	DFS	Quartile	III,IV	0.678	0.871	.004	26	view →
READ	DFS	Quartile	II,III,IV	0.312	0.706	.015	24	view →
LIHC	DFS	Quartile	All	0.285	0.530	<.001	24	view →
BLCA	DFS	Quartile	IV	0.372	0.123	.014	16	view →
CESC	OS	Median	III,IV	0.428	0.796	.003	12	view →
UVM	DFS	Median	All	0.676	0.452	.021	8	view →
LGG	DFS	Quartile	All	0.358	0.520	.006	7	view →
COAD	DFS	Median	II,III,IV	0.727	0.561	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

DDX11L2–KIRC (DFS)

Open the KIRC breakdown →