DDX11

Across TCGA cell cohorts, DDX11 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DDX11-associated genes across cancer lineages are GSG1L2, DEFA5, and C5orf67. Each is linked with DDX11 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX11-to-partner and partner-to-DDX11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by DDX11-low versus DDX11-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX11→partner) and Y-score (partner→DDX11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GSG1L2 →	+0.010	+3.700	<.001	.009	3	2
OVARY	DEFA5 →	+0.108	+4.990	<.001	.001	3	1
STOMACH	C5orf67 →	+0.160	+4.432	<.001	.003	3	1
LUNG_NSCLC_LUAD	CAPZA3 →	+0.063	+2.962	.008	.007	3	1
LUNG_NSCLC_LUAD	C9orf57 →	+0.014	+2.830	<.001	.005	3	1
BLOOD_Lymphoma	SLC22A8 →	+0.054	+4.350	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

GSG1L2 by DDX11 expression — SKIN

Explore this box plot interactively →