DDX10

Across TCGA cell cohorts, DDX10 mutation is significantly associated with the RNA expression of many other genes, with 299 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDX10-associated genes across cancer lineages are GDF5-AS1, LCE1F, and MYF5. Each is linked with DDX10 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX10-to-partner and partner-to-DDX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GDF5-AS1 grouped by DDX10-low versus DDX10-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX10→partner) and Y-score (partner→DDX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GDF5-AS1 →	+0.018	+2.874	<.001	.009	3	2
LUNG_SCLC	LCE1F →	+0.107	+4.643	<.001	.004	3	2
BLOOD_Lymphoma	MYF5 →	+0.007	+3.925	<.001	.006	3	1
BLOOD_Lymphoma	ACE2 →	+0.020	+3.842	<.001	.002	3	1
BLOOD_Lymphoma	TCERG1L →	+0.227	+3.165	.002	.004	3	1
BLOOD_Lymphoma	OR4E2 →	+0.002	+3.925	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 299 associations by consensus.

GDF5-AS1 by DDX10 expression — BLOOD_Lymphoma

Explore this box plot interactively →