DDTL

Across TCGA patient cohorts, DDTL mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDTL-associated genes across cancer lineages are RNU6-1270P, NPIPA2, and MIR3152. Each is linked with DDTL in more than 1 cancer types. Because this analysis shows association rather than direction, both DDTL-to-partner and partner-to-DDTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1270P grouped by DDTL-low versus DDTL-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDTL→partner) and Y-score (partner→DDTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-1270P →	+0.518	+7.640	<.001	.009	3	1
BLCA	NPIPA2 →	+0.054	+7.640	<.001	.009	3	1
BLCA	MIR3152 →	+0.407	+7.640	<.001	.009	3	1
KIRC	MIR99A →	+0.466	+6.293	<.001	.001	3	1
KIRC	MIR514A2 →	+0.472	+5.579	<.001	.004	3	1
KIRC	SETP15 →	+0.101	+5.199	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

RNU6-1270P by DDTL expression — BLCA

Explore this box plot interactively →