DDT

Across TCGA patient cohorts, DDT RNA expression is significantly associated with the go_rna of many other GO terms, with 7,158 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible DDT-associated GO terms across cancer lineages are Regulation of termination of DNA-templated transcription, Golgi to endosome transport, and Regulation of small GTPase mediated signal transduction. Each is linked with DDT in more than 24 cancer types. Because this analysis shows association rather than direction, both DDT-to-partner and partner-to-DDT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of termination of DNA-templated transcription grouped by DDT-low versus DDT-high in DLBC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDT→partner) and Y-score (partner→DDT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	Regulation of termination of DNA-templated transcription →	-0.084	-0.894	<.001	<.001	3	25
DLBC	Golgi to endosome transport →	-0.094	-1.068	<.001	<.001	3	24
STAD	Regulation of small GTPase mediated signal transduction →	-0.040	-0.461	<.001	<.001	3	23
THYM	Substrate-dependent cell migration →	-0.071	-0.754	<.001	<.001	3	23
ESCA	Tissue homeostasis →	-0.033	-0.479	<.001	<.001	3	23
DLBC	Peptidyl-serine autophosphorylation →	-0.089	-0.872	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,158 associations by consensus.

Regulation of termination of DNA-templated transcription by DDT expression — DLBC

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