DDT

Across TCGA pan-cancer cohorts, DDT RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated DDT data layer compared with 1 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher DDT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DDT expression acts as an unfavorable survival marker, although some lineages such as KIRP and LIHC show a favorable association.

KICH, ACC, and UVM are the cancer types where DDT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	II,III,IV	0.557	1.000	.001	95	view →
ACC	DFS	Median	All	0.197	0.724	<.001	86	view →
UVM	OS	Median	III,IV	0.230	0.836	.001	56	view →
HNSC	OS	Tertile	All	0.508	0.747	.006	42	view →
UCEC	DFS	Median	All	0.563	0.724	<.001	42	view →
SKCM	OS	Median	II,III,IV	0.304	0.476	.009	23	view →
KIRP	DFS	Median	III,IV	0.790	0.168	.011	18	view →
UCS	DFS	Tertile	IV	0.361	0.981	.024	18	view →
LAML	DFS	Median	All	0.374	0.540	.008	18	view →
ESCA	DFS	Tertile	III,IV	0.227	0.532	<.001	16	view →
LIHC	DFS	Median	All	0.602	0.483	.006	15	view →
OV	OS	Median	II,III,IV	0.879	0.804	.028	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

DDT–KICH (OS)

Open the KICH breakdown →