DDT

Across TCGA cell cohorts, DDT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,134 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DDT-associated GO terms across cancer lineages are Negative regulation of macrophage migration, Negative regulation of macrophage chemotaxis, and Protein localization to microtubule plus-end. Each is linked with DDT in more than 16 cancer types. Because this analysis shows association rather than direction, both DDT-to-partner and partner-to-DDT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of macrophage migration grouped by DDT-low versus DDT-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDT→partner) and Y-score (partner→DDT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of macrophage migration →	+0.861	+3.442	.002	<.001	3	17
SOFT_TISSUE	Negative regulation of macrophage chemotaxis →	+0.535	+2.215	<.001	<.001	3	15
BLOOD_Lymphoma	Protein localization to microtubule plus-end →	+0.245	+0.762	.001	<.001	3	9
BLOOD_Lymphoma	Protein localization to microtubule end →	+0.245	+0.762	.001	<.001	3	9
OVARY	Mitochondrial potassium ion transmembrane transport →	+0.130	+1.131	<.001	<.001	3	9
LIVER	GDP-mannose biosynthetic process →	+0.130	+0.736	<.001	.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,134 associations by consensus.

Negative regulation of macrophage migration by DDT expression — SOFT_TISSUE

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