DDT

Across TCGA cell cohorts, DDT mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible DDT-associated genes across cancer lineages are GPR26, MYF5, and OR2T6. Each is linked with DDT in more than 1 cancer types. Because this analysis shows association rather than direction, both DDT-to-partner and partner-to-DDT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR26 grouped by DDT-low versus DDT-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDT→partner) and Y-score (partner→DDT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR26 →	+0.016	+5.228	<.001	.005	3	1
OVARY	MYF5 →	+0.023	+5.807	<.001	.001	3	1
OVARY	OR2T6 →	+0.063	+5.196	<.001	.005	3	1
OVARY	CDRT15L2 →	+0.022	+5.196	<.001	.005	3	1
OVARY	OR2M3 →	+0.053	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GPR26 by DDT expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →