DDR2

Across TCGA pan-cancer cohorts, DDR2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DDR2 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DDR2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DDR2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

UCEC, PDAC, and LSCC are the cancer types where DDR2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.778	1.000	.007	20	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
LSCC	DFS	Tertile	All	0.202	0.792	.010	4	view →
GBM	OS	Quartile	All	0.387	0.659	.027	2	view →
HNSC	OS	Median	II,III,IV	0.625	0.862	.034	2	view →
CCRCC	OS	Median	All	1.000	0.572	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DDR2–UCEC (DFS)

Open the UCEC breakdown →