DDR2

Across TCGA pan-cancer cohorts, DDR2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DDR2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DDR2 RNA is repressed in tumor relative to normal tissue. In most cancer types DDR2 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and BLCA are the cancer types where DDR2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDR2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−1.667	<.001	10	view →
COAD	Female	II,III,IV	−1.590	<.001	10	view →
BLCA	Male	All	−2.494	<.001	8	view →
LUSC	Female	All	−1.535	<.001	8	view →
KICH	Female	All	−1.891	<.001	7	view →
KIRP	Male	All	−1.492	<.001	7	view →
UCEC	All	All	−3.475	<.001	6	view →
BRCA	All	III,IV	−2.049	<.001	6	view →
LUAD	Female	All	−1.021	<.001	6	view →
STAD	Female	All	−1.728	.008	3	view →
HNSC	Female	III,IV	+1.200	.023	3	view →
READ	Female	All	−3.070	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

DDR2–THCA

Open the THCA breakdown →