DDR2

Across TCGA patient cohorts, DDR2 mutation is significantly associated with the RNA expression of many other genes, with 2,040 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDR2-associated genes across cancer lineages are FCER1A, CKS2, and GINS2. Each is linked with DDR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DDR2-to-partner and partner-to-DDR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCER1A grouped by DDR2-low versus DDR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDR2→partner) and Y-score (partner→DDR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FCER1A →	-0.626	-1.947	.001	<.001	3	4
STAD	CKS2 →	+0.833	+3.355	.004	.005	3	4
UCEC	GINS2 →	+0.679	+3.392	<.001	<.001	3	4
COAD	MND1 →	+0.596	+3.362	.005	.004	3	4
UCEC	CDCA2 →	+0.575	+1.787	.002	.007	3	3
UCEC	MAPKAPK5-AS1 →	+0.333	+2.818	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,040 associations by consensus.

FCER1A by DDR2 expression — UCEC

Explore this box plot interactively →