DDR2

Across TCGA patient cohorts, DDR2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDR2-associated genes across cancer lineages are Cyclin-B1, Notch1, and p27_pT198. Each is linked with DDR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDR2-to-partner and partner-to-DDR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by DDR2-low versus DDR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDR2→partner) and Y-score (partner→DDR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.431	+2.584	.020	.010	3	3
UCEC	Notch1 →	+0.168	+2.428	<.001	.001	3	2
UCEC	p27_pT198 →	+0.112	+2.459	.001	.018	3	2
UCEC	p90 RSK →	+0.141	+2.009	.024	.005	3	2
UCEC	S6_pS240_S244 →	+0.326	+3.335	.014	.005	3	2
UCEC	STAT3_pY705 →	-0.304	-1.999	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Cyclin-B1 by DDR2 expression — UCEC

Explore this box plot interactively →