DDR2

Across TCGA cell cohorts, DDR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,350 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DDR2-associated GO terms across cancer lineages are Vesicle cargo loading, Response to molecule of fungal origin, and Metanephric glomerulus morphogenesis. Each is linked with DDR2 in more than 11 cancer types. Because this analysis shows association rather than direction, both DDR2-to-partner and partner-to-DDR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vesicle cargo loading grouped by DDR2-low versus DDR2-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDR2→partner) and Y-score (partner→DDR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Vesicle cargo loading →	+0.107	+0.415	<.001	<.001	3	12
BLOOD_Lymphoma	Response to molecule of fungal origin →	-1.324	-1.343	<.001	<.001	3	9
CNS	Metanephric glomerulus morphogenesis →	+1.025	+1.492	<.001	<.001	3	9
CNS	Metanephric glomerulus vasculature morphogenesis →	+1.025	+1.492	<.001	<.001	3	9
CNS	Metanephric glomerular capillary formation →	+1.025	+1.492	<.001	<.001	3	9
LIVER	Positive regulation of early endosome to late endosome transport →	+0.132	+2.290	<.001	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,350 associations by consensus.

Vesicle cargo loading by DDR2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →