DDR2

Across TCGA cell cohorts, DDR2 mutation is significantly associated with the RNA expression of many other genes, with 612 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDR2-associated genes across cancer lineages are CCR8, TMEM207, and KHDRBS2. Each is linked with DDR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDR2-to-partner and partner-to-DDR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCR8 grouped by DDR2-low versus DDR2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDR2→partner) and Y-score (partner→DDR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
SOFT_TISSUE	TMEM207 →	+0.022	+5.369	<.001	.004	3	1
OESOPHAGUS	KHDRBS2 →	+0.603	+4.906	<.001	.006	3	1
LUNG_SCLC	MYL10 →	+0.055	+3.523	.007	.008	3	1
LUNG_SCLC	OR12D3 →	+0.004	+4.058	<.001	.007	3	1
LUNG_SCLC	LYZL2 →	+0.016	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 612 associations by consensus.

CCR8 by DDR2 expression — SOFT_TISSUE

Explore this box plot interactively →