DDR1-DT

Across TCGA pan-cancer cohorts, DDR1-DT RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of DDR1-DT’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DDR1-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDR1-DT is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, LUSC, and LIHC are the cancer types where DDR1-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDR1-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.019	<.001	8	view →
LUSC	All	All	+0.034	<.001	5	view →
LIHC	All	All	+0.005	.002	5	view →
UCEC	All	III,IV	+0.025	.029	4	view →
THCA	All	All	−0.011	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

DDR1-DT–HNSC

Open the HNSC breakdown →