DDOST

Across TCGA patient cohorts, DDOST protein abundance is significantly associated with the RNA expression of many other genes, with 16,190 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DDOST-associated genes across cancer lineages are ZNF510, ADCY5, and TTC5. Each is linked with DDOST in more than 5 cancer types. Because this analysis shows association rather than direction, both DDOST-to-partner and partner-to-DDOST results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DDOST versus ZNF510 in GBM, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDOST→partner) and Y-score (partner→DDOST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZNF510 →	-0.526	-0.210	<.001	.003	3	6
BRCA	ADCY5 →	-1.056	-0.394	.004	<.001	2	6
LSCC	TTC5 →	-0.471	-0.194	<.001	.004	3	5
BRCA	MYO9A →	-0.532	-0.292	<.001	.003	3	5
COAD	CGRRF1 →	-0.403	-0.184	.003	.005	3	4
GBM	SYP →	-1.330	-0.336	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,190 associations by consensus.

DDOST vs ZNF510 — GBM

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